Endocrine Abstracts

Background: The study aimed to establish a mouse model of Graves’ disease (GD) with Graves’ ophthalmopathy (GO; GD+GO) that can represent the clinical disease characteristics.Methods: A eukaryotic expression plasmid of insulin-like growth factor 1 receptor (IGF-1R) α subunit (pcDNA3.1/IGF-1Rα) and a thyrotropin receptor (TSHR) A subunit plasmid (pcDNA3.1/TSHR-289) were injected in female BALB/c mice to induce a GD+GO model. Grouping w...

Tobacco smoke (TS) is the major cause of lung cancer, including pulmonary neuroendocrine tumors such as small cell lung cancer and large cell neuroendocrine carcinoma. Unlike squamous cell carcinomas and adenocarcinomas, the precursor lesions for subtypes of pulmonary neuroendocrine tumors have not been historically defined, and theexpression of neuroendocrine markers has been served as critical indices for the identification of these tumors. Mitogen-activated protein kinases ...

Fat accumulation, lipogenesis and glycolysis are key contributors to hepatocyte metabolic reprogramming and the pathogenesis of non-alcoholic liver fatty liver disease (NAFLD). The molecular mechanisms affected by steatosis and inflammation in the obese state remain unknown. Here we report that obesity leads to dysregulated expression of protein-tyrosine phosphatases in human livers. Protein Tyrosine Phosphatase Receptor Kappa (PTPRK) levels were increased in hepatocytes by st...